What is H4CBD? Quick info
- UNSER KRAUT Media
- Mar 1, 2024
- 3 min read
Updated: Oct 27, 2024
What is H4CBD?
H4CBD is a brand new cannabinoid on the market. It is made from CBD by hydration and is said to be up to 100 times more potent than CBD at affecting CB1 receptors.
H4CBD is not a derivative of HHC or THC and is therefore described as the legal alternative to THC.
CBD or H4CBD?
Scientists in Todd's group have known about H4CBD since the 1940s, but it's only recently that this hydrogenated form of CBD has come into the spotlight. As CBD has reached incredible levels of popularity that no one would have previously imagined possible, the demand for more alternatives that may offer even better benefits has increased tremendously.
Furthermore, in 2006, scientists discovered that H4CBD has a binding affinity to the CB1 receptor and that H4CBD has stronger anti-inflammatory biomarkers than conventional CBD. Simply a stronger CBD in certain areas.
Are CBD and H4CBD opponents?
Rather than thinking of H4CBD and CBD as rivals, consider the advantages of each: CBD could be the weaker, all-natural option, while H4CBD would serve as a more optimized, stronger alternative. As modern cannabinoid research continues to advance rapidly, both CBD and H4CBD will surely continue to play central roles.
Does H4CBD make you high?
In general, CBD has a lower affinity for the CB1 receptors. The CB1 receptor mediates the effects of endogenous cannabinoids as well as exogenously administered cannabinoids in the central nervous system and is therefore a component of the endocannabinoid system. You can find out more about this in our blog post.
However, in combination with four hydrogen atoms (hence the name H4CBD), the affinity of CBD to the CB1 receptors apparently increases considerably, making the new cannabinoid H4CBD more psychoactive.
H4CBD has a 100-fold greater binding affinity for the human CB1 receptor (Ki = 145 nm) than CBD (Ki = >10 µm), putting it in the same range as CBN in terms of its psychoactive potential, perhaps slightly stronger. Although H4CBD is 100 times more psychoactive than CBD, its psychoactive properties are still less than THC and HHC.
Is H4CBD legal?
Products containing fully hydrogenated H4CBD have a low and undetectable THC content. Therefore, it is legal in all countries where CBD is legal.
Sources and references
Ben-Shabat, S., Hanuš, L.O., Katzavian, G., & Gallily, R. (2006, January 6). New cannabidiol derivatives: synthesis, binding to cannabinoid receptors, and evaluation of their anti-inflammatory activity. Journal of Medicinal Chemistry, 49(3), 1113–1117. Retrieved from https://pubs.acs.org/doi/10.1021/jm050709m
Laprairie, RB, Bagher, AM, Kelly, MEM, & Denovan-Wright, EM (2015, October). Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. British Journal of Pharmacology, 172(20), 4790–4805. Retrieved from https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.13250
Morales, P., Reggio, PH, & Jagerovic, N. (2017, June 28). A review of the medicinal chemistry of synthetic and natural derivatives of cannabidiol. Frontiers in Pharmacology, 8. Retrieved from https://www.frontiersin.org/articles/10.3389/fphar.2017.00422/full

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For legal reasons, we would like to point out that the effects of hemp and cannabinoids (CBD) described here refer exclusively to public scientific reports and specialist reports, publications and user experiences and are not to be understood as instructions for use or promises of healing. The text is in no way a substitute for professional advice from a doctor and may not be used as a basis for independent diagnosis and the start, change or termination of treatment of diseases. Always consult your trusted doctor if you have any health questions or complaints!
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